Our lab is dedicated to improving society’s ability to prepare for, manage, and heal from infectious disease outbreaks using mathematical models, statistical inference, and digital technology.
Linking within- and between-host pathogen dynamics
Epidemics are self-similar across multiple scales: the rise and fall of cases during an outbreak are mirrored by the rise and fall of viral load during an infection. To control epidemics, we need to understand how within-host pathogen dynamics translate into between-host transmission events. We develop adaptive experimental designs and statistical approaches to infer viral kinetics and their relationship with contagiousness, lending insights into outbreak dynamics, optimal epidemic control, and the fundamental characteristics of viruses themselves.
Connecting interpersonal contact networks and mobility with disease transmission
Pathogens have only limited power over their own ability to spread; the rest is up to the structure of our communities. Human interactions are unbelievably complex, and this complexity can give rise to unexpected patterns of viral transmission and evolution. We seek to understand this relationship between human behavior and pathogen transmission by measuring critical contact network structures and modeling the behavior of pathogens as they spread through highly structured, dynamic populations.
Mapping the ecology of co-circulating respiratory pathogens
Pathogens rarely spread in an ecological vacuum. Instead, microbes must jockey for a foothold against both related strains and unrelated species, all while their hosts try to inhibit their spread. The co-circulation of pathogens poses a major public health challenge, since every pathogen features distinct transmission and disease characteristics. However, it also opens potential opportunities, where well-placed resources can be optimally distributed to monitor and control the spread of many pathogens at once. We study the ecological relationships between respiratory pathogens, paying special attention to the perturbations in transmission that were brought on by behavioral changes during the COVID-19 pandemic. Using mathematical models, we infer immunological and environmental factors that influence the joint transmission of respiratory pathogens and design strategies for their optimal surveillance and control.
In prep, submitted, in press
- Drivers of racial/ethnic disparities in antibiotic consumption in the United States
Stephen M. Kissler*, Scott W. Olesen*, Sanjat Kanjilal, Daphne S. Sun, Yonatan H. Grad. medRxiv (2022) 10.1101/2021.12.09.21266965
- Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: a retrospective cohort study
James A. Hay*, Stephen M. Kissler*, Joseph R. Fauver*, Christina Mack*, Caroline G. Tai, Radhika M. Samant, Sarah Connolly, Deverick J. Anderson, Gaurav Khullar, Matthew MacKay, Miral Patel, Shannan Kelly, April Manhertz, Isaac Eiter, Daisy Salgado, Tim Baker, Ben Howard, Joel T. Dudley, Christopher E. Mason, Manoj Nair, Yaoxing Huang, John DiFiori, David D. Ho, Nathan D. Grubaugh, Yonatan H. Grad. eLife (2022) 10.1101/2022.01.13.22269257
- Impact of respiratory infection and chronic comorbidities on early pediatric antibiotic dispensing in the United States
Stephen M. Kissler, Bill Wang, Ateev Mehrotra, Michael Barnett, Yonatan H. Grad. Clinical Infectious Diseases (2022) 10.1093/cid/ciac811
- Viral Dynamics of SARS-CoV-2 Variants in Vaccinated and Unvaccinated Persons
Stephen M. Kissler*, Joseph R. Fauver*, Christina Mack*, Caroline G. Tai, Mallery I. Breban, Anne E. Watkins, Radhika M. Samant, Deverick J. Anderson, Jessica Metti, Gaurav Khullar, Rachel Baits, Matthew MacKay, Daisy Salgado, Tim Baker, Joel T. Dudley, Christopher E. Mason, David D. Ho, Nathan D. Grubaugh, Yonatan H. Grad. New England Journal of Medicine (2021) 10.1056/NEJMc2102507
- Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies
Stephen M. Kissler*, Joseph Fauver*, Christina Mack*, Caroline Tai, Mallery Breban, Anne E. Watkins, Radhika Samant, Deverick Anderson, Jessica Metti, Gaurav Khullar, Rachel Baits, Matthew MacKay, Daisy Salgado, Tim Baker, Joel T. Dudley, Christopher E. Mason, David Ho, Nathan D Grubaugh, Yonatan Grad. PLOS Biology (2021) 10.1371/journal.pbio.3001333
- Waning Immunity and the Second Wave: Some Projections for SARS-CoV-2
Chryssi Giannitsarou, Stephen M. Kissler, Flavio Toxvaerd. American Economic Review: Insights (2021) 10.1257/aeri.20200343
- Childhood respiratory outpatient visits correlate with socioeconomic status and drive geographic patterns in antibiotic prescribing
Stephen M. Kissler, R. Monina Klevens, Michael Barnett, Yonatan H. Grad. Journal of Infectious Diseases (2021) 10.1093/infdis/jiab218
- Reduction in antibiotic prescribing attainable with a gonococcal vaccine
Stephen M. Kissler*, Moriah Mitchell*, Yonatan H. Grad. Clinical Infectious Diseases (2021) 10.1093/cid/ciab276
- Model-informed COVID-19 vaccine prioritization strategies by age and serostatus
Kate M. Bubar, Kyle Reinholt, Stephen M. Kissler, Marc Lipsitch, Sarah Cobey, Yonatan H. Grad, Daniel Larremore. Science (2021) 10.1126/science.abe6959
- Projecting the transmission dynamics of SARS-CoV-2 through the post-pandemic period
Stephen M. Kissler*, Christine Tedijanto*, Edward Goldstein, Yonatan H. Grad, Marc Lipsitch. Science (2020) 10.1126/science.abb5793
- Reductions in commuting mobility are correlated with geographic differences in SARS-CoV-2 prevalence in New York City
Stephen M. Kissler*, Nishant Kishore*, Malavika Prabhu, Dena Goffman, Yaakov Beilin, Ruth Landau, Cynthia Gyamfi-Bannerman, Brian T. Bateman, Jon Snyder, Armin S. Razavi, Daniel Katz, Jonathan Gal, Angela Bianco, Joanne Stone, Daniel Larremore, Caroline O. Buckee, Yonatan H. Grad. Nature Communications (2020) 10.1038/s41467-020-18271-5
- Distinguishing the roles of antibiotic stewardship and reductions in outpatient visits in generating a five-year decline in antibiotic prescribing
Stephen M. Kissler, R. Monina Klevens, Michael L. Barnett, Yonatan H. Grad. Clinical Infectious Diseases (2020) 10.1093/cid/ciaa269
- Symbolic transfer entropy reveals the age structure of pandemic influenza transmission from high-volume influenza-like illness data
Stephen M. Kissler, Cecile Viboud, Bryan Grenfell, Julia Gog. J Roy Soc Interface (2020) 10.1098/rsif.2019.0628
- Surveillance to maintain the sensitivity of genotype-based antibiotic resistance diagnostics
Allison L. Hicks, Stephen M. Kissler, Marc Lipsitch, Yonatan H. Grad. Plos Biology (2019) 10.1371/journal.pbio.3000547
- Geographic transmission hubs of the 2009 influenza pandemic in the United States
Stephen M. Kissler, Julia R. Gog, Cécile Viboud, Vivek Charu, Ottar N. Bjørnstad, Lone Simonsen, Bryan T. Grenfell. Epidemics (2018) 10.1016/j.epidem.2018.10.002
- Urbanization and humidity shape the intensity of influenza epidemics in U.S. cities
Benjamin D. Dalziel, Stephen Kissler, Julia R. Gog, Cecile Viboud, Ottar N. Bjørnstad, C. Jessica E. Metcalf, Bryan T. Grenfell. Science (2018) 10.1126/science.aat6030
- Contagion! The BBC Four Pandemic — the model behind the documentary
Petra Klepac, Stephen Kissler, Julia Gog. Epidemics (2018) 10.1016/j.epidem.2018.03.003
- Determination of personalized diabetes treatment plans using a two-delay model
Stephen M. Kissler, Cody Cichowitz, Sriram Sankaranarayanan, and David M. Bortz. Journal of Theoretical Biology (2014) 10.1016/j.jtbi.2014.06.005
- Let’s finally get COVID-19 testing right
Stephen Kissler. The Hill (2021)
- If control measures are stopping flu in its tracks, why aren’t they stopping coronavirus?
Stephen Kissler. The Conversation (2021)
Stephen Kissler. Harvard Public Health Magazine (2020)
- Coronavirus: does the common cold protect you from COVID?
Stephen Kissler. The Conversation (2020)
- Will flu or cold viruses push the new coronavirus out of circulation this winter?
Stephen Kissler. The Conversation (2020)
- Making Hepatitis C a rare disease in the United States
Victor Roy, Dave Chokshi, Stephen Kissler, and Prabhjot Singh. Health Affairs Forefront (2016) 10.1377/forefront.20160615.055364